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Antiviral biphenyl derivatives
专利权人:
JANSSEN PHARMACEUTICALS; INC.
发明人:
DUAN, MAOSHENG,CHEN, PINGYUN,COUCH, RICKY,GRIMES, RICHARD MARTIN,KAZMIERSKI, WIESLAW MIECZYSLAW,TALLANT, MATTHEW,NORTON, BETH ADAMS
申请号:
PE2012000291
公开号:
PE20120993A1
申请日:
2010.08.26
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
It refers to an abiotic formula compound (III),Among them, R1 is h or C1-C3 tar; R2 is C1-C3 tar; R3 is h, or a 4, 5 or 6 saturated helical rings are formed with carbon atoms. - di-di-di-di-di-di-di-di-di-di-di-di-di-di-di-di-di-di-methyl-propyl] carbamate (4,4 '- diphenylglycol {1h-imidazol-4,2-diil [(3S, 7S, 9S) - 7,9-dimethyl-6, 10-dioxa-2-azastiro[4.5]decan-3,2-diil][(2S)-3-metr-1-oxo-1,2-butandil]](bicarbamato de dimetyl,[1 (1 s) - 2-methyl-1 - ((2 s) - 2 - [4 - (4) (2 ------ {2 - (3 s) - 2 - ((2 s) - 3-methyl-2 - ((methyl oxygen) carbon) amine} dinoy-6, 10 dioxin-2-azaspiro - [4.5] dec-3-il] - 1-diphenyl-methyl-methyl-methyl-methyl-methyl-methyl-methyl-methyl-methyl-methyl-methyl-methyl (1), including, among other things, a base base base base base (1). A pharmaceutical composer was also mentioned These antiviral compounds are useful tools for the treatment of hepatitis C virus infectionREFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (III), DONDE R1 ES H O ALQUILO C1-C3; R2 ES ALQUILO C1-C3; R3 ES H O JUNTO CON EL ATOMO DE CARBONO AL QUE ESTA UNIDO FORMA UN ANILLO ESPIRO SATURADO DE 4, 5 O 6 MIEMBROS. SON COMPUESTOS PREFERIDOS: [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-DIMETIL-2-((2S)-3-METIL-2-{[(METILOXI)CARBONIL]AMINO}BUTANOIL)-6,10-DIOXA-2-AZASPIRO[4,5]DEC-3-IL]-1H-IMIDAZOL-4-IL}-4-BIFENIL)-1H-IMIDAZOL-2-IL]-1-PIRROLIDINIL}CARBONIL)-2-METILPROPIL]CARBAMATO DE METILO, (4,4'-BIFENILDIILBIS{1H-IMIDAZOL-4,2-DIIL[(3S,7S,9S)-7,9-DIMETIL-6,10-DIOXA-2-AZASPIRO[4,5]DECAN-3,2-DIIL][(2S)-3-METIL-1-OXO-1,2-BUTANDIIL]})BISCARBAMATO DE DIMETILO, [(1S)-2-METIL-1-({(2S)-2-[4-(4'-{2-[(3S)-2-((2S)-3-METIL-2-{[(METILOXI)CARBONIL]AMINO}BUTANOIL)-6,10-DIOXA-2-AZASPIRO-[4.5]DEC-3-IL]-1H-IMIDAZOL-4-IL}-4-BIFENILIL)-1H-IMIDAZOL-2-IL]-1-PIRROLIDINIL}CARBONIL)PROPIL]CARBAMATO DE METILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS ANTIVIRALES SON UTILES EN EL TRATAMIENTO DE INFECCIONES POR VIRUS DE LA HEPATITIS C
来源网站:
中国工程科技知识中心
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