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AURISTATIN DERIVATIVES, LINKER-DRUGS AND LIGAND-DRUG CONJUGATES
专利权人:
发明人:
申请号:
EP16196894.6
公开号:
EP3165532A3
申请日:
2016.11.02
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently, hydrogen, amino, nitro, halogen, hydroxyl, C1-C6 alkoxy, carboxylic acid, C1-C6 alkoxycarbonyl, C1-C6 amino, C1-C6 aminocarbonyl, C1-C6 alkyl, branched C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclic, aryl or heteroaryl, provided at least one of R1 and R3 is an amino group. A linker-drug and a ligand-drug conjugate including the compound are also provided.
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