Disclosed is a pranlukast solid dispersion composition with an improved and a method of manufacturing the same. More particularly, the present invention provides a pranlukast solid dispersion manufactured by a hot－melting process using a composition comprising pranlukast and at least one water－soluble polymer selected from the group consisting of polyvinylpyrrolidone vinylacetate copolymer, polyvinylpyrrolidone and polyvinylalcohol, which has greatly improved dissolution rate and bioavailability as compared to those prepared by the conventional spray－drying method, thus enabling to obtain the equivalent pharmaceutical effects with less amount of a drug.本發明揭示出一種經改良的普侖斯特(pranlukast)固態分散物組成物及其製造方法。更特別的是，本發明提供一種利用熱熔融方法，使用一包含普侖斯特與至少一種選自於由下列所組成之群之可溶於水的聚合物(聚乙烯吡咯啶酮醋酸乙烯酯共聚物、聚乙烯吡咯啶酮及聚乙烯醇)之組成物所製造的普侖斯特固態分散物，其與利用習知之噴灑乾燥方法所製備的那些比較時，已大大改良溶解比例及生物可利用率，因此能夠以較少的藥物量獲得相等的醫藥效應。
