Disclosed are compositions and methods comprising povidone-iodine and a cooling-effective amount of a chemical agent. The compositions are useful to relieve mild ocular irritation, enhance ocular comfort, and to provide a refreshing effect and improved sensation, when the povidone-iodine solution is applied to the eye.本發明揭示包含聚乙烯吡咯啶酮-碘及冷卻有效量之化學劑的組成物和方法。當將該聚乙烯吡咯啶酮-碘溶液施用於眼睛時,該組成物可用於紓緩輕度之眼部刺激、增強眼部舒適及提供消除疲勞的功效和改善感覺。