The present invention is directed to a solid composition as a tablet or a capsule or liquid composition for use in the treatment of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). The composition comprises a zinc salt of a carboxylic acid wherein the amount of zinc ion is within 20 and 60 mg for the solid tablet or capsule, or 2 and 20 mg for 1 ml for the liquid composition, and a polyphenol of formula (I) wherein the polyphenol (I) is selected from the group formed by 3',4',5,7-tetrahydroxyflavone, 4',5,7-trihydroxyflavone, 4',5,6,7,8-pentamethoxyflavone, 6-hydroxyflavone, 5,6,7-trihydroxyflavone and 5,6,7,4'-tetrahydroxyflavone the amount within 10 and 50 mg for each tablet or capsule.
