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Base Composition of fexofenadine and preparation procedure, or compressed, use of the composition
专利权人:
SANOFI-AVENTIS
发明人:
LAMOUREUX GAEL,LESOT AXELLE
申请号:
ARP110101365
公开号:
AR081539A1
申请日:
2011.04.20
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
Relates to Granules of fexofenadine, and a composition containing a Coating procedure called "Hot Hot Melt coated hot melt) of fexofenadine.The Coating procedure in hot "hot melt of a Masked Coating u00bb fexofenadine allows effective without its Bitter Taste, on the other hand, unacceptably Slow dissolution.Claim 1: fexofenadine composition comprising (a) a Central Granules formed by grains of active principle, in the presence of Binder and optionally LUBRICANT or preference of diluent and (b) a coating layer of the centre formed Granules Matrix composition in the Fat that fexofenadine represents less than 10%.Preferably 15% or even 20% in weight relative to the weight of the composition; the active principle represents up to 90%, preferably up to 60%, or 50% in weight relative to the weight of the composition, or even less than 40% by weight relative to the weight of the composition.Preferably, the active principle represents 20% to 40% relative to the weight of the composition; The Matrix Fat represents more than 10% by weight, preferably 50% to 85% by weight of the composition, optionally a Matrix comprising Fat adjuvant, preferably chosen from the age Efore Hydrophilic Surfactants, and their mixtures.And the latter representing less than 10% by weight of the composition, preferably 1 to 3% by weight relative to the weight of the composition; The Binder Agent, preferably a Hydrophilic Polymers selected from Hydrophilic hot melt or agents, representing 0.2% to 18% in PE The Weight ratio of the composition of the granule CoatedPreferably the Binder is less than 18% by weight for a hot melt or even Agent preferably the Binder is less than 10% by weight to a Hydrophilic polymer with relation to the weight of the composition; The diluent, if necessary, as is a cargo Agent Level from 0 to 78.8%, preferably from 0 to 39%, preferably 5 to 15% by weight,With the weight of the composition; The Oil, if necessary, as a Flow Agent represents a level of 0 to 1.8% with relat
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