Jon Graham Anthony Steadman;Daryl Simon Walter;Jorge Munoz-Muriedas;Mairi Sime;Giancarlo Trani;David Kenneth Dean;Rachel Elizabeth Anne Thewlis;Ian David Wall
发明人:
David Kenneth Dean,Jorge Munoz-Muriedas,Mairi Sime,Jon Graham Anthony Steadman,Rachel Elizabeth Anne Thewlis,Giancarlo Trani,Ian David Wall,Daryl Simon Walter
申请号：
US13266557
公开号：
US20120172366A1
申请日:
2010.04.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof:wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl, or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description.The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis or osteoarthritis or neurodegenerative disorders.
