DÉRIVÉ DE 3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE EN TANT QUE INHIBITEUR DE P2X7 POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES

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专利权人:

PFIZER PRODUCTS INC.

发明人:

申请号：

EP03778700.9

公开号：

EP1581232B1

申请日:

2003.12.19

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis； allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

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