Disclosed is an antimicrobial silicone rubber, functional macromolecules being chemically bonded to the surface of the silicone rubber and containing vinyl or ethynyl, and the functional macromolecules being chemically bonded to the surface of the silicone rubber by means of vinyl or ethynyl； the functional macromolecules comprise polyamino acid macromolecules of which the molecular structure is as shown in (I) and (II). The antimicrobial silicone rubber of the present invention has polyamino acid macromolecules chemically bonded to the surface of the silicone rubber and serves an antimicrobial function by means of the interaction of polyamino acid macromolecules with a negatively charged cell membrane in bacteria, providing a persistent antimicrobial effect and unlikely causing bacteria to develop any drug resistance； moreover, polyamino acid macromolecules bind to the surface of the silicone rubber by means of chemical bonding, preventing macromolecules from being precipitated and entering a cell, providing good biocompatibility.
