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Monocyclic pyridine derivative
专利权人:
Eisai R&D Management Co.; Ltd.
发明人:
FUNASAKA, Setsuo,OKADA, Toshimi,TANAKA, Keigo,NAGAO, Satoshi,OHASHI, Isao,YAMANE, Yoshinobu,NAKATANI, Yusuke,KAROJI, Yuki
申请号:
ES14754294
公开号:
ES2628495T3
申请日:
2014.02.18
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound represented by the following formula (IA) or a pharmaceutically acceptable salt thereof: ** Formula ** wherein n represents 0 to 2; A represents a C6-10 arylene group or a C3-5 heteroarylene group; G represents a single bond, an oxygen atom or -CH2-; E represents a non-aromatic C3-5 heterocycle containing nitrogen; R1 represents a cyano group, a mono (C1-6 alkyl) amino group, a di (C1-6 alkyl) amino group, a C2-6 alkyl group optionally substituted by 1 to 3 halogen atoms, a C1-6 alkoxy group optionally substituted by 1 to 3 halogen atoms, or a hydroxyl group, a C1-6 alkoxy group C1-6 alkyl optionally substituted by 1 to 3 halogen atoms; or a C1-6 alkoxy group C1-6 alkoxy optionally substituted by 1 to 3 halogen atoms; R2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a C2-6 acyl group optionally substituted by a substituent selected from an S group described below, a C1-6 alkyl group optionally substituted by 1 to 3 atoms of halogen, a C1-6 hydroxyalkyl group optionally substituted by 1 to 3 halogen atoms or a non-aromatic C3-5 heterocyclic group containing nitrogen; R3 represents a hydrogen atom, an oxo group, a C1-6 alkyl group optionally substituted by 1 to 3 halogen atoms or a C1-6 alkoxy group optionally substituted by 1 to 3 halogen atoms; R4 represents a C1-6 alkyl group, with the proviso that when E represents an azetidine ring and R2 or R3 is present in a nitrogen atom in the azetidine ring, R2 or R3 does not represent a hydrogen atom; and the group S represents a group consisting of a hydroxyl group, a mono (C1-6 alkyl) amino group, a di (C1-6 alkyl) amino group, a C1-6 alkoxy group and a C3-5 heterocyclic group not aromatic containing nitrogen.Un compuesto representado por la siguiente fórmula (IA) o una sal farmacéuticamente aceptable del mismo:**Fórmula** en donde n representa 0 a 2; A representa un grupo arileno C6-10 o un grupo heteroarileno C3-5; G representa un enlace simple, un átomo de oxígeno o -CH2-; E representa un het
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