Kalyanam Nagabhushanam;Rajendran Ramanujam;Muhammed Majeed;Renukeshwar H Chandramouli
发明人:
Muhammed Majeed,Kalyanam Nagabhushanam,Rajendran Ramanujam,Renukeshwar H Chandramouli
申请号：
US13175016
公开号：
US08193156B1
申请日:
2011.07.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility； (ii) enhanced rate of dissolution in water； (iii) enhanced bioavailability； (iv) excellent vascular endothelial growth factor promoting activity； (v) excellent anti-5-alpha-reductase activity； (vi) capabilities to prevent/reduce “hair fall” and promote “hair growth”, thereby maintaining a perfect homeostasis for “hair care”. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.
