Stéphane De Lombaert,Daniel R. Goldberg,Kenneth Brameld,Eric Brian Sjogren,Andrew Scribner
申请号：
US15978361
公开号：
US20180256574A1
申请日:
2018.05.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.
