DE LOMBAERT, St‚phane,GOLDBERG, Daniel R,BRAMELD, Kenneth,SJOGREN, Eric Brian,SCRIBNER, Andrew
申请号：
PH12016500416
公开号：
PH12016500416B1
申请日:
2016.03.03
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.
