Systems and methods for multi-modality data processing are provided. Some embodiments are particularly directed to enhancing and measuring multi-modality medical data. In one embodiment, a method for enhancing medical data in a medical processing system includes receiving, by the medical processing system, a reference set of medical data. The reference set of medical data may be display on a first user display. A region identifier, which corresponds to a region to be enhanced, is received along with an enhancement selection. A target set of data is identified based on the received region identifier and the received enhancement selection, and the medical processing system performs an enhancement corresponding to the enhancement selection upon the target set of data. The enhanced target set of data may be displayed on a second user display, the second user display being different from the first user display.
