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Bicyclic substituted Uracils and their use
专利权人:
Bayer Pharma AG;Bayer Pharma Aktiengesellschaft
发明人:
FÜRSTNER, Chantal,ACKERSTAFF, Jens,STRAUB, Alexander,MEIER, Heinrich,TINEL, Hanna,ZIMMERMANN, Katja,TERSTEEGEN, Adrian,ZUBOV, Dmitry,KAST, Raimund,SCHAMBERGER, Jens,SCHÄFER, Martina,BÖRNGEN, Kirsten,FÜRSTNER CHANTAL,ACKERSTAFF JENS,ACKERSTAFF, JENS,STRAUB ALEXANDER,STRAUB, ALEXANDER,MEIER HEINRICH,MEIER, HEINRICH,TINEL HANNA,TINEL, HANNA,ZIMMERMANN KATJA,ZIMMERMANN, KATJA,TERSTE
申请号:
ES13720407
公开号:
ES2581537T3
申请日:
2013.05.03
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of the formula (I) ** Formula ** in which R1 represents hydrogen or (C1-C4) alkyl, R2 represents a group of the formula ** Formula ** in which * represents the atom binding site of uracil nitrogen, A represents -CH2-, -CH2-CH2-, -O-CH2- or oxygen, where it represents the phenyl ring binding site, m represents a number 0, 1 or 2, R4 represents halogen, difluoromethyl, trifluoromethyl, (C1-C4) alkyl, difluoromethoxy, trifluromethoxy or alkoxy- (C1-C4), R5A represents hydrogen or deuterium, R5B represents hydrogen, deuterium or (C1-C4) alkyl, R6 represents hydrogen or fluorine, R7 represents hydrogen or fluorine, R8 represents halogen, difluoromethyl, trifluoromethyl, (C1-C4) alkyl or nitro, R9 represents hydrogen, halogen, difluoromethyl, trifluoromethyl, (C1-C4) alkyl, nitro or (C1-C4) -thio alkyl, R3 represents a group of the formula ** Formula ** in which it represents the binding site to the uracil nitrogen atom, the ring Q represents sits 5 to 7 membered heterocycle or 5 or 6 membered heteroaryl, 5 wherein the 5-7 membered heterocycle or the 5 or 6 membered heteroaryl may be substituted with 1 to 4 substituents independently selected from the halogen group, difluoromethyl, trifluoromethyl, trideuterometyl, (C1-C6) alkyl, cycloalkyl (C3-C7), oxo, hydroxyl, (C1-C4) alkyl -carbonyl, (C1-C4) alkoxycarbonyl and aminocarbonyl (C1-C4) -sulfonyl , wherein the (C1-C6) alkyl and the (C3-C7) cycloalkyl, in turn, may be substituted with 1 to 3 substituents independently selected from the group of halogen, cyano, trifluoromethyl, cycloalkyl (C3-C7), hydroxyl , (C1-C4) alkoxy and 4- to 7-membered heterocycle, and wherein two (C1-C6) alkyl radicals attached to a carbon atom of the 5-7 membered heterocycle and the 5- or 6-membered heteroaryl, together with the carbon atom to which they are attached, can form a 3- to 6-membered carbocycle, R24 represents halogen, to (C1-C4) alkyl or (C1-C4) alkoxy, n represents the number 0, 1, 2 or 3, and the salts, solvates and solvate
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