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Thiazole or oxazole P2X7 receptor antagonists substituted
专利权人:
AXXAM S.p.A.
发明人:
PEVARELLO, Paolo,LOHMER, Stefan,LIBERATI, Chiara,SENECI, Pierfausto,PESENTI, Cristina,PRANDI, Adolfo
申请号:
ES15705523
公开号:
ES2670093T3
申请日:
2015.02.04
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of the following formula (I) or a pharmaceutically acceptable salt thereof: ** Formula ** which includes any stereochemically isomeric form thereof, in which n is 1 or 2; Y represents oxygen or sulfur; each of R1 and R2 is independently selected from the group consisting of hydrogen, deuterium, halogen, C1-C4 alkyl, optionally substituted with hydroxy or halogen, such as hydroxymethyl, fluoromethyl, difluoromethyl, trifluoromethyl, C3-C6 cycloalkyl, optionally substituted with hydroxy or halogen, or C1-C4 alkyloxy; each of R3 and R4 is independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, difluoromethyl, trifluoromethyl, r C1-C4 alkyloxy, NR9R10, wherein R9 and R10 are independently hydrogen or C1-C4 alkyl, or 2-thiazolidin-1,1-dione; or the two R3 groups or the R3 and R4 groups taken together form a six-membered heterocyclic ring containing a nitrogen atom; R5 is selected from hydrogen, halogen, or is a heterocyclic ring selected from pyrimidin-2-yl, pyridin-2-yl or pyrazin-2-yl, optionally substituted with halogen, C1-C4 alkyl, fluoromethyl, difluoromethyl, trifluoromethyl or alkyloxy C1-C4; R7 is hydrogen or C1-C4 alkyl; the radical ** Formula ** represents an optionally substituted azetidine, pyrrolidine, piperidine, morpholine, oxazepane or 1,2,3,4-tetrahydroisoquinoline ring, in which each of R6 is independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 spirocycloalkyl difluoromethyl, trifluoromethyl, C1-C4 alkyloxy, aryl, heteroaryl, C1-C4 aryloxy or C1-C4 aryloxy group in which the aryl group or heteroaryl group is optionally substituted with halogen C1-C4 alkyl, fluoromethyl, difluoromethyl, trifluoromethyl or C1-C4 alkyloxy.Un compuesto de la siguiente fórmula (I) o una sal farmacéuticamente aceptable del mismo:**Fórmula** que incluye cualquier forma estereoquímicamente isomérica del mismo, en el que n es 1 o 2; Y representa oxígeno o azufre; cada uno de R1 y R2 se
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