BHAT, ABHIJIT SURESH,BRADSHAW, CURT WILLIAM,LAURENT, OLIVIER ALEXANDRE,PRESTON, RICHARD RYAN,TUMELTY, DAVID,WOOD, LAUREN DIANE,YU, WEI HONG,LEE, ALICE
申请号：
CA2804185
公开号：
CA2804185A1
申请日:
2011.07.11
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL?) comprising K188 according to Kabat numbering； a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.
