БХАТ Абхиджит Суреш (US),БРЭДШОУ Курт Уилльям (US),ЛОРАН Оливье Александр (US),ПРЕСТОН Ричард Райан (US),ТАМЕЛТИ Дэвид (US),ВУД Лорен Дайан (US),ЙУ Вэй Хон (US),ЛИ Элис (US)
申请号：
RU2012157167/10
公开号：
RU2012157167A
申请日:
2011.07.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A multifunctional antibody conjugate (MAC) comprising (1) an antibody or antigen binding portion thereof comprising at least a kappa light chain constant region fragment (CLk) containing K and H according to Kabat numbering； (2) a linker comprising the formula XYZ, where Z represents a group covalently linked to the antibody through the side chain K, Y represents a linear or branched biocompatible connecting chain, and X represents a group covalently linked to at least one effector group, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates and prodrugs. 2. The MAC of claim 1, further comprising D-CLk. 3. MAC according to claim 1, where the CLk region contains at least residues 62-103 of SEQ ID NO: 15, SEQ ID NO: 45, SEQ ID NO: 46 or SEQ ID NO: 47.4. MAC according to claim 1, where the CLk region contains at least residues 1-106 of SEQ ID NO: 15, SEQ ID NO: 45, SEQ ID NO: 46 or SEQ ID NO: 47.5. MAC no. 1, where the effector moiety is conjugated to MAC only according to KCLk. 6. The MAC of claim 1, wherein the effector moiety is conjugated to a MAC at KCLk on at least one light chain and at one other position on the antibody. A MAC according to claim 1, wherein the effector moiety is conjugated to a MAC at KCLk on at least one light chain and at two other positions on the antibody. The MAC of claim 1, wherein the effector moiety is conjugated to CLk K on both light chains. MAC according to claim 1, wherein the effector moiety is conjugated to CLk K on only one light chain. The MAC of claim 1, wherein the effector moiety is a therapeutic agent, protein, peptide, nucleic acid, aptamer, small molecule, protein agonist, protein antagonist, metabolic regulator, hormone, toxin, growth factor, or diagnostic1. Полифункциональный антительный конъюгат (MAC), содержащий(1) антитело или его антигенсвязующий участок, содержащий по меньшей мере фрагмент константной области легкой цепи каппа (CLk), содержащий Kи Hсогласно нумерации по Kabat；(2) линкер, включ
