The present invention provides a mouse with a UV light sterilizing device comprising: a mouse, a plurality of UV LED lamps and a control unit. The mouse has a casing and a plurality of openings provided on the casing, and each opening is provided with a plurality of light guide plates arranged in a fin grid shape; a plurality of UV LED lamps are disposed on the mouse In the body, and through the reflective layer of the light guide plate to reflect ultraviolet light, and direct ultraviolet light to the inside and outside of the mouse housing, and the control unit is used to control the activation and shutdown of each of the UV LED lamps, and further The bactericidal effect of the ultraviolet light on the whole mouse is achieved at regular intervals.