Maria Seifer;Jean-Pierre Sommadossi;David Standring;April Patty
发明人:
David Standring,Jean-Pierre Sommadossi,April Patty,Maria Seifer
申请号：
US13052750
公开号：
US08158606B2
申请日:
2011.03.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
It has been discovered that β-L-2′-deoxynucleosides are active against drug-resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided that includes administering a β-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. In addition, a method for preventing lamivudine resistant HBV (M552V) mutation from occurring in a naïve host is provided that includes administering a β-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. A method for preventing and/or suppressing the emergence of the HBV double mutant (L528M/M552V) in a host is also provided that includes administering a β-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug.
