Angeline Ingrid Bartholomeusz,Stephen Locarnini,Anna Ayres,Margaret Littlejohn,Paul Desmond,Peter William Angus
申请号：
US13760039
公开号：
US09701982B2
申请日:
2013.02.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
