DERIVE DE PYRAZOLE, COMPOSITION MEDICINALE CONTENANT CE DERIVE, UTILISATION THERAPEUTIQUE DE CEUX-CI ET INTERMEDIAIRE POUR LA PRODUCTION DE CETTE COMPOSITION
The present invention provides pyrazole derivativesrepresented by the general formula:(see formula I)wherein R1 represents H, an optionally substituted C1-6 alkylgroup etc.； one of Q and T represents a group represented bythe general formula:(see formula II)or a group represented by the general formula:(see formula III)while the other represents an optionally substituted C1-6 alkylgroup etc.； R2 represents H, a halogen atom, OH, an optionallysubstituted C1-6 alkyl group etc.； X represents a single bond,O or S； Y represents a single bond, a C1-6 alkylene group etc. ；Z represents CO or SO2； R4 and R5 represent H, an optionallysubstituted C1-6 alkyl group etc.； and R3, R6 and R7 representH, a halogen atom etc., pharmaceutically acceptable salts thereofor prodrugs thereof, which exhibit an excellent inhibitoryactivity in human SGLT1 and are useful as agents for the preventionor treatment of a disease associated with hyperglycemia suchas diabetes, diabetic complications or obesity, andpharmaceutical compositions comprising the same,pharmaceutical uses thereof, and intermediates for productionthereof.
