PARIKH, INDU,MISHRA, AWADHESH K.,DONGA, ROBERT,VACHON, MICHAEL G.
申请号：
CA2349203
公开号：
CA2349203C
申请日:
1999.11.19
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Rapidly dispersing solid dry therapeutic dosage form comprised of a waterinsoluble compound existing as a nanometer or micrometer particulate solidwhich is surface stabilized by the presence of at least one phospholipid, theparticulate solid being dispersed throughout a bulking matrix. When the dosageform is introduced into an aqueous environment the bulking matrix issubstantially completely dissolved within less than 2 minutes therebyreleasing the water insoluble particulate solid in an unaggregated and/orunagglomerated state. The matrix is composed of a water insoluble substance ortherapeutically useful water insoluble or poorly water soluble compound, aphospholipid and optionally also at least one non-ionic, anionic, cationic oramphipathic surfactant, together with a matrix or bulking agent and if neededa release agent. The volume weighted mean particle size of the water insolubleparticle is 5 micrometers or less.
