The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.本發明係關於包含結合之肺炎鏈球菌(Streptococcus pneumoniae)莢膜醣抗原(糖結合物)之新穎免疫原組合物及其用途。本發明之免疫原組合物通常將包含至少一種來自沒有出現在Prevnar、Synflorix及/或Prevnar 13中之肺炎鏈球菌血清型之糖結合物。本發明亦係關於使用該等新穎免疫原組合物針對肺炎球菌感染對人類個體,具體而言嬰兒及老年人進行疫苗接種。