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MICRO-NEEDLE AND MATRIX MICRO-NEEDLE
专利权人:
МЕДРЭКС КО., ЛТД. (JP);ТЕЙДЗИН ЛИМИТЕД (JP)
发明人:
ТОЙОХАРА Киецуна (JP),ТАНАКА Таиси (JP),КОХНО Кадзутеру (JP),ОДА Такаси (JP),МАСАОКА Коити (JP),КОБАЯСИ Кацунори (JP),ИСИБАСИ Масаки (JP),ХАМАМОТО Хидетоси (JP)
申请号:
RU2014147308
公开号:
RU2014147308A
申请日:
2013.04.24
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A microneedle for transdermal administration of a drug, which includes an upper section, a core section and a lower section, in which (i) the angle at the apex of the tip of the microneedle (α) is from 15 ° to 60 °; (ii) the diameter of the tip microneedle (D) is from 1 μm to 20 μm; (iii) the area (A) of the upper surface of the lower section is larger than the area (A) of the lower surface of the core section; (iv) the following expressions (1) and (2) are satisfied (where H is the full height, and D is the diameter of the lower surface of the lower section) (where β is the angle between the lateral surface thyu of the core section and the upper surface of the lower section, and α is the angle at the apex of the end of the microneedle) and (v) the solid composition containing the drug is attached to the side surface of the core section, and the following expression (5) is satisfied (where γ is the angle formed by the tangent lines connecting the top of the upper section and the surface of the solid composition attached to the side surface of the core sections) .2. A microneedle according to claim 1, wherein the solid composition comprises a water-soluble polymer as a binder component. A microneedle according to claim 1, which has a total height (H) in the range from 120 μm to 800 μm. A microneedle according to claim 1, which satisfies the following expression (6) (where A: area of the upper surface of the lower section, A: area of the lower surface of the core section) .5. A microneedle according to claim 1, wherein the height (H) of the lower section is from 100 μm to 500 μm. A microneedle according to claim 1, which contains a thermoplastic resin as a main component. The microneedle according to claim 6, in which the thermoplastic resin is at least one resin selected from the group consisting of polycarbonates, polypropylene, polymers cycle1. Микроигла для трансдермального введения лекарственного средства, которая включает в себя верхнюю секцию, стержневую сек
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