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MICRO-AIGUILLE ET MATRICE DE MICRO-AIGUILLES
专利权人:
MEDRX CO., LTD.;TEIJIN LIMITED
发明人:
TOYOHARA, KIYOTSUNA,TANAKA, TAISHI,KOHNO, KAZUTERU,ODA, TAKASHI,MASAOKA, KOICHI,KOBAYASHI, KATSUNORI,ISHIBASHI, MASAKI,HAMAMOTO, HIDETOSHI
申请号:
CA2871575
公开号:
CA2871575A1
申请日:
2013.04.24
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The purpose of the present invention is to provide a microneedle and microneedle array able to support not only a drug but also a stabilizer or thickener in large quantities, and offering favorable puncture properties. The present invention is a microneedle for administering a drug percutaneously, the microneedle comprising a distal end section, a shaft section, and a base section; (i) the distal end apex angle (a) being in the range of 15-60°; (ii) the distal end diameter (D0) being in the range of 1 to 20 µm; (iii) the area (A3) of the base section upper surface being greater than the area (A2) of the shaft section bottom surface; (iv) formulae (1) and (2) being satisfied: H/D4=3 (1) (H is the overall height and D4 is the diameter of the base section bottom surface) and ß = 90-0.5a (2) (ß is the angle formed by a side surface of the shaft section and the base section upper surface, and a is the distal end apex angle); and (v) a solid composition containing the drug being fixed to the side surface of the shaft section and satisfying formula (5): 10 ° = ? = 60 ° (5) (? is the angle formed by tangent lines that connect the apex point of the distal end section and points on the surface of the solid composition fixed to the surface of the shaft section on either side).
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