Kiyoshi Tachikawa,Joseph E. Payne,Padmanabh Chivukula
申请号：
US14667678
公开号：
US20150307880A1
申请日:
2015.03.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention provides UNA oligomers for selectively inhibiting V30M TTR expression, which can be used in treating amyloidosis. The UNA oligomers can have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers being UNA monomers and nucleic acid monomers. Embodiments include pharmaceutical compositions and methods for treating or preventing TTR-related amyloidosis by administering a UNA oligomer to a subject.
