TACHIKAWA, Kiyoshi,PAYNE, Joseph E.,CHIVUKULA, Padmanabh
申请号：
EP15769096
公开号：
EP3122365A4
申请日:
2015.03.24
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
This invention provides UNA oligomers for selectively inhibiting V30M TTR expression, which can be used in treating amyloidosis. The UNA oligomers can have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers being UNA monomers and nucleic acid monomers. Embodiments include pharmaceutical compositions and methods for treating or preventing TTR-related amyloidosis by administering a UNA oligomer to a subject.
