The invention concerns therapeutic compositions for the treatment of vascularizing cancers especially glioblastoma. In particular the invention is directed to compositions that comprise a molecule having a binding ability that is specific for B7 H3 and a molecule having a binding ability that is specific for a cell surface factor (or its receptor) that is involved in promoting tumor angiogenesis (especially VEGF or its receptor VEGFR). The invention is additionally directed to the use of such compositions in the treatment of such cancers and in particular in the treatment of glioblastoma.
