The present invention provides a novel free base crystalline form of 3-Z-[1-4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene-6-methoxycarbonyl-2-indolinone and a method for manufacturing the same. The present invention further provides a pharmaceutical preparation containing the crystalline form and its use for treating diseases, for example, treating angiogenic eye diseases in particular.本發明提供了3-Z-[1-(4-(N-((4-甲基-呱嗪-1-基)-甲羰基)-N-甲基-胺基)-苯胺基)-1-苯基-亞甲基]-6-甲氧羰基-2-吲哚啉酮的新游離鹼晶型及其製備方法，還提供了含有所述晶型的藥物製劑及其用於治療疾病特別是用於治療血管生成性眼部疾病的用途。
