PETTERSSON, Martin Youngjin,AM ENDE, Christopher William,JOHNSON, Douglas Scott,KAUFFMAN, Gregory Wayne,STEPAN, Antonia Friederike,VERHOEST, Patrick Robert
申请号：
PE2017001310
公开号：
PE20171318A1
申请日:
2016.01.26
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a compound of formula I, where: X is a 5-14 membered heteroaryl containing 1 to 3 heteroatoms； R1 is hydrogen, halogen, among others； R2a and R2b are hydrogen, halogen, cyano, among others； R4a and R4b are hydrogen, halogen, oxo, among others； R5a and R5b are hydrogen, halogen, SF5, among others； R6 and R7 are hydrogen, halogen, among others； R10 is halogen, cyano, among others； R11 is halogen, cyano, among others； y is an integer of 1, 2, 3 or 4. Preferred compounds are: 2 - {[(1aS, 6bR) -4-fluoro-1a-methyl-5- (trifluoromethoxy) -1,1a-dihydro-6bH- cyclopropa [b] [1] benzofuran-6b-yl] methyl} -7- (4-methyl-1H-imidazol-1-yl) -3,4-dihydro-2H-pyrido [1,2-a] pyrazin- 1,6-dione；2 - [(1As, 6br) - 3-fluoro-1a-methyl-5 - (trifluoromethane) - 1, 1a-dihydro-6bh-cyclopapa [b] [1] benzofuran-6b-il] methyl} - 7 - (4-methyl-1h-imidazole-1-il) - 3, 4-dihydro-2h-pyridan [1, 2-A] pyridan-1, 6-dioxin, etc. He also mentioned a pharmaceutical composer These compounds are gamma Secretariat modulators that can be used to treat neurodegenerative and neurological diseases such as Alzheimer's and Down's syndrome.Se refiere a un compuesto de formula I, donde: X es un heteroarilo de 5 a 14 miembros que contiene 1 a 3 heteroatomos； R1 es hidrogeno, halogeno, entre otros； R2a y R2b son hidrogeno, halogeno, ciano, entre otros； R4a y R4b son hidrogeno, halogeno, oxo, entre otros； R5a y R5b son hidrogeno, halogeno, SF5, entre otros； R6 y R7 son hidrogeno, halogeno, entre otros； R10 es halogeno, ciano, entre otros； R11 es halogeno, ciano, entre otros； y es un numero entero de 1, 2, 3 o 4. Son compuestos preferidos: 2-{[(1aS, 6bR)-4-fluoro-1a-metil-5-(trifluorometoxi)-1,1a-dihidro-6bH-ciclopropa[b][1]benzofuran-6b-il]metil}-7-(4-metil-1H-imidazol-1-il)-3,4-dihidro-2H-pirido[1,2-a]pirazin-1,6-diona； 2-{[(1aS, 6bR)-3-fluoro-1a-metil-5-(trifluorometoxi)-1,1a-dihidro-6bH-ciclopropa[b][1]benzofuran-6b-il]metil}-7-(4-metil-1H-imidazol-1-il)-3,4-dihidro-2H-pirido[1,2-a]pirazin-1,6-diona； entre
