YONSEI UNIVERSITY;INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
PARK, JI YONG,JEONG, CHAN MIN,LEE, MIN KYUNG,CHOI, SUNG WON,CHO, YOUNG HEE,JEONG, HOON OK
申请号：
EP08765978
公开号：
EP2209468A4
申请日:
2008.05.29
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to a chitosan capsule in which a soluble active ingredient is encapsulated in a matrix containing chitosan and phytic acid； a cross-linking method and materials capable of being used in preparing the capsule； and pharmaceutical, food and cosmetic compositions comprising the capsule. The chitosan capsule according to the present invention is prepared via ionic gelation of chitosan as a biodegradable polymer with phytic acid capable of rapidly and effectively forming a cross-linking reaction with the chitosan polymer. The capsule of the present invention shows high encapsulation efficiency for a soluble active ingredient and protects the soluble active ingredient from being damaged in a digestive tract, resulting in improving an in vivo delivery efficiency of a physiologically active material. Further, since the capsule of the present invention has a pH-dependent sustained-release mechanism which can minimize the release of a soluble active ingredient in the stomach and gradually release in the intestine, it is possible to regulate sustained-release of a soluble active ingredient.
