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High concentration antibody and protein formula
专利权人:
BAYER HEALTHCARE LLC
发明人:
XINGHANG MA,JUN XIANG
申请号:
ARP130103099
公开号:
AR092400A1
申请日:
2013.08.30
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
A high concentration formula is provided, but there is no antibody salt or other protein, and these formulas are basically isomerized and low viscosity. Procedures for the treatment of diseases using published formulas are also defined. 1. Claim 1: salt free protein or antibody formula, including: (a) 10 mm to 30 mm hysteria; (b) 50 ppm to 200 ppm non-ionic surfactant; (c) 88 mm to 292 mm sugar or alcohol selected from manitol, dextrosa, glucosa, trehalosa and sucrose; (d) 0 mm to 50 mm argina; (E) 0 mm to 50 mm lysine; (f) Glycerin or alachlor from 0 mm to 133 mm; (g) alachlor from 0 mm to 10 mm;(h) In the 150 mg / ml protein or antibody, 20 mg / ml; in the formula of the protein or antibody, the pH value is between pH 4.0 and pH 6.0, and the protein formula basically does not contain inorganic salt. 13. Claim 4: the preparation of salt-free protein or antibody in any one of the requirements, that is, the non-ionic surfactant is a polymer selected from polyurethane 20 and polyurethane 80. Claim 5: production of salt-free protein or antibody in claim 1, wherein sugar is sugar. 7. Claim 7: protein or salt free antibody in claim 1,These include: (a) 30 mm histidina, (b) 100 ppm polyurethane 80, (c) 292 mm sugar, and (d) 20 mg / ml protein or antibody, where the pH of the protein or antibody varies from pH 5.0 to pH 6.0. 150. Claim 17: a salt-free anti-F D C antibody comprising: (a) 10 mm to 30 mm hysteria; (b) 50 ppm to 200 ppm non-ionic surfactant; (c) 88 mm to 292 mm sugar or sugar selected from manitol, dextrosa, glucasa, trehalosa and sucrose; (d) 0 mm to 50 mm argon; (E) 0 mm to 50 mm lysine; (f) 0 mm to 50 mm lysine. Mm-133 mm of glycerol or alachlor, (g) 0 mm to 10 mm of alachlor, and (H) 20 mg / ml to 150 mg / ml of antiretroviral antibodies;The pH value of this anti phosphate antibody formula is 4.0-6.0, but this anti phosphate antibody formula basically does not contain inorganic salt. 150. Claim 22: the preparation of anti TFPI antibody containing no salt a
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