The present invention provides a pharmaceutical carrier combination, a pharmaceutical composition containing the same, its use, its preparation method and its use method. The drug carrier combination includes a first mixed material and a second mixed material. The first mixed material includes a hydrophilic polymer material, tricalcium phosphate and a water-soluble dispersant. The second mixed material includes a moisturizing material and divalent cation salts. The pharmaceutical composition comprises the aforementioned pharmaceutical carrier combination and pharmaceutical ingredients. The pharmaceutical composition is used for preparing anti-inflammatory drugs or antibiotic drugs. The preparation method of the drug carrier combination includes mixing the components in the first mixed material and mixing the components in the second mixed material. The use method of the drug carrier combination is to mix the first mixed material with the drug component, and then mix with the second mixed material. Through the above-mentioned drug carrier combination, the effect of effective drug release at the surgical site can be achieved.本發明係提供一種藥物載體組合、包含其的藥物組合物、其用途、其製備方法及其使用方法。該藥物載體組合包含一第一混合材料及一第二混合材料。該第一混合材料包括親水性高分子材料、三鈣磷酸以及水溶性分散劑。該第二混合材料包括保濕材料以及二價陽離子鹽類。該藥物組合物包含前述藥物載體組合及藥物成分。該藥物組合物用於製備抗發炎藥物或抗生素藥物。該藥物載體組合的製備方法為將該第一混合材料中的各成分混合以及將該第二混合材料中的各成分混合。該藥物載體組合的使用方法為將該第一混合材料與藥物成分混合,再與該第二混合材料混合。透過如上所述之藥物載體組合,可以達到在手術部位有效地釋放藥物的效果。