TEEGARDEN, BRADLEY,XIONG, YIFENG,STRAH-PLEYNET, SONJA,JAYAKUMAR, HONNAPPA,DOSA, PETER I.,FEICHTINGER, KONRAD,CASPER, MARTIN,LEHMANN, JUERG,JONES, ROBERT M.,UNETT, DAVID J.,CHOI, JIN SUN KAROLINE
申请号：
CA2588513
公开号：
CA2588513C
申请日:
2005.11.17
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to certain 3-phenyl-pyrazole derivatives ofFormula (Ia) and pharmaceutical compositions thereof that modulate theactivity of the 5-HT2A serotonin receptor. Compounds and pharmaceuticalcompositions thereof are directed to methods useful in the treatment ofplatelet aggreagation, coronary artery disease, myocardial infarction,transient ischemic attack, angina, stroke, atrial fibrillation, reducing therisk of blood clot formation, asthma or symptoms thereof, agitation or asymptom, behavioral disorders, drug induced psychosis, excitative psychosis,Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis,psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOSschizophrenia and related disorders, and sleep disorders, sleep disorders,diabetic-related disorders, progressive multifocal leukoencephalopathy and thelike. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor mediated disorders in combination with otherpharmaceutical agents administered separately or together.
