Philip Wilson HOWARD,Stephen John GREGSON,Jean-Noel LEVY
申请号：
US15510345
公开号：
US20170239365A1
申请日:
2015.09.11
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A conjugate comprising a PBD dimer linked from the tether joining the two PBD units, wherein the linker is of formula (A1): (Formula (A1)) wherein RN1 is selected from H and C1-4 alkyl； L is a linker connected to a cell binding agent； CBA is the cell binding agent； n is an integer selected in the range of 0 to 48； Q is: (Formula (Q)), where Qx is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue.
