UHEREK CHRISTOPH,ZUBER CHANTAL,CZELOTH NIKLAS,BRUECHER CHRISTOPH,ROTTGEN PETER,OSTERROTH FRANK,ENGLING ANDRE,DAELKEN BENJAMIN
申请号：
NZ60089910
公开号：
NZ600899A
申请日:
2010.11.30
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is humanized antibody or fragment thereof capable of binding to interleukin-l0 (IL-10), wherein said antibody or fragment thereof comprises a variable light chain comprising the amino acid sequences of CDR 1, CDR2 and CDR3 of the murine antibody B-NI0 variable light chain, and a variable heavy chain comprising the amino acid sequences of CDR1, CDR2 and CDR3 of the murine B-NI0 variable heavy chain, wherein the variable heavy chain further comprises the residues Asn73 and Ser74 of SEQ ID NO: 55 or the corresponding position of the variable heavy chain.
