Chandrashekhar P. Pathak;Peter G. Edelman;Amarpreet S. Sawhney
发明人:
Chandrashekhar P. Pathak,Amarpreet S. Sawhney,Peter G. Edelman
申请号：
US11985588
公开号：
US08535705B2
申请日:
2007.11.16
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.
