A use of milk extract in the preparation of composition for preventing, remission of or treating rheumatoid arthritis is provided a use of milk extract in the preparation of composition for regulating Th1 response is provided a use of milk extract in the preparation of composition for preventing, remission of or treating swelling resulted from autoimmune response is provided. Each 100 g of said milk extract contains 80 g or more protein and 600 mg or more immunoglobulin G.本發明提供一種乳汁萃取物之用途,用於製備預防、緩解、或治療類風濕性關節炎的組成物、製備調節第一型輔助性T細胞反應的組成物或製備預防、緩解、或治療自體免疫反應所致四肢腫脹的組成物,其中每100公克之該乳汁萃取物含有80公克以上的蛋白質量且具有大於600毫克的免疫球蛋白G。