Provided are a pharmaceutical composition for preventing and/or treating osteoarthritis comprising an extract of Angelica gigas Nakai, a pharmaceutical composition for preventing and/or treating osteoarthritis comprising a mixed extract of Angelica gigas Nakai and Cnidium officinale, and a method of preventing and/or treating osteoarthritis comprising administering the extract of Angelica gigas Nakai or the mixed extract of Angelica gigas Nakai and Cnidium officinale.