The Brigham and Women's Hospital,Inc.;Massachusetts Institute of Technology
发明人:
Robert S. Langer,Carlo Giovanni Traverso,Sahab Babaee,Simo Pajovic,Jiuyun Shi
申请号：
US16684638
公开号：
US20200155821A1
申请日:
2019.11.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Residence devices for long term delivery of therapeutic compounds and/or for sensing one or more relevant parameters in vivo are disclosed. In one embodiment, a residence device may include a plurality of links interconnected by a corresponding plurality of flexible hinges to permit the residence device to be deformed into a contracted configuration and subsequently permitted to return to an expanded configuration once positioned in a desired location, such as the stomach, of a subject. In some instances, at least a portion of the interconnected links may include a first link segment, a second link segment, and a coupling that selectively connects the first link segment to the second link segment. The coupling may be configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature to selectively weaken and/or disassemble the residence device.
