The present invention relates to a method of treating gastrointestinal stromal tumors (GIST), especially GIST, which is progressing after imatinib therapy or after imatinib and sunitinib therapy, using a combination comprising (a) a c-kit inhibitor and (b) a PI3K inhibitor or FGFR inhibitor.La presente invención se refiere a un método para tratar tumores de estroma gastrointestinal (GIST), especialmente GIST, que progresa después de la terapia con imatinib o después de la terapia con imatinib y sunitinib, usando una combinación que comprende (a) un inhibidor de c-kit y (b) un inhibidor de P13K o inhibidor de FGRF.