The present invention relates to a method of treating gastrointestinal stromal tumors (GIST), especially GIST, which is progressing after imatinib therapy or after imatinib and sunitinib therapy, using a combination comprising (a) a c-kit inhibitor and (b) a dual KIT inhibitor and FGFR inhibitor or FGFR inhibitor.本發明係關於使用包含(a)c-kit抑制劑及(b)雙重KIT抑制劑及FGFR抑制劑或FGFR抑制劑之組合治療胃腸道基質瘤(GIST),尤指在伊馬替尼(imatinib)療法或伊馬替尼及舒尼替尼(sunitinib)療法之後惡化之GIST之方法。