파에르그만 얀,요한슨 구드문두르,올슨 클라어스,바트첼러 데렉 그레고리,욘슨 요르겐,토르넬 얀
申请号：
KR1020177016732
公开号：
KR1020170086597A
申请日:
2015.11.24
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The goal of this study was to determine whether the combination of TRIAC, DHEA or triiodothyro acetic acid (TRIAC) and dehydroepiandrosterone (DHEA), compared with placebo alone, on corticosteroid induced effects on human collagen synthesis The effect is to investigate. Six healthy male applicants aged 40-65 participated. Four sites of abdominal skin were pretreated with Betamethasone valerate cream for 3 weeks. The same site was then treated with TRIAC, DHEA, TRIAC + DHEA and one of the placebo alternatives in the same cream vehicle for two weeks. Thereafter, the suction vesicle was evacuated from each of these sites by means of a vacuum pump. Blister fluid from each site was collected and frozen until analysis. Analysis of the amino terminal propeptide of human type I procollagen (PINP) in inhaled blister fluid was performed using a commercially available Orion Diagnostics kit. This study has for the first time shown that the combination of TRIAC and DHEA can effectively stimulate collagen synthesis in skin pretreated with betamethasone valerate as demonstrated by the increase in PINP and that this compound is more effective than TRIAC or DHEA alone . This combination can be used to effectively treat skin atrophy in corticosteroid-induced skin atrophy. It can also be used to treat skin atrophy and other skin atrophy due to other conditions such as sun-damaged skin. Another area of interest would be the use of TRIAC and DHEA in combination with potent corticosteroids to prevent corticosteroid induced skin atrophy. If this compound is still effective in the treatment of eczema and psoriasis without the risk of skin atrophy, this compound may be a major breakthrough for the use of potent topical corticosteroids.본 연구의 목표는, 인간에서 콜라겐 합성에 대한 코르티코스테로이드 유도된 효과에 대한 TRIAC, DHEA 또는 위약 단독과 비교된, 트라이요오도타이로아세트산(TRIAC) 및 데하이드로에피안드로스테론(DHEA)의 복합제의 효과를 조사하는 것이다. 40-65세의 6명의 건강한 남성 지원자가 참여하였다. 복부 피부의 4개소 부위를 베타메타손 발레레이트 크림에 의해 3주 동안 전치료하였다. 이후, 동일한 부위를 2주 동안 동일한 크림 비히클 중에 TRIAC, DHEA
