The purpose of this study was to compare the effects of triiodothyroacetic acid (TRIAC) and dehydroepiandrosterone (DHEA) in combination with TRIAC, DHEA, or placebo alone on corticosteroid-induced effects on collagen synthesis in humans. It was to investigate. Six healthy male human volunteers aged 40 to 65 participated. Four areas of the abdominal skin were pretreated with betamethasone valerate cream for 3 weeks. The same area was then treated for 2 weeks with one of the following options in the same cream vehicle: TRIAC, DHEA, TRIAC + DHEA and placebo. Thereafter, in each of these areas, suctioning herpes was caused by a vacuum pump. Herpes zoster fluid from each area was collected and frozen until analysis. Analysis of human type I procollagen amino terminal propeptide (PINP) in aspirated herpes fluids was performed using a commercially available Orion Diagnostics kit. This study shows that the combination of TRIAC and DHEA can effectively stimulate collagen synthesis in skin pretreated with betamethasone valerate, as evidenced by an increase in PINP, and the combination of TRIAC or DHEA It was first shown to be more effective than alone. This combination can be used to effectively treat skin atrophy in corticosteroid-induced skin atrophy. This combination may also be used to treat skin atrophy due to other conditions (eg, due to skin damaged by sunlight) and skin atrophy due to old age. Another interesting application is to combine TRIAC and DHEA with potent corticosteroids to prevent corticosteroid-induced skin atrophy. If this combination is still effective in the treatment of eczema and psoriasis and there is no risk of skin atrophy, this combination represents a breakthrough in the use of potent topical corticosteroids. [Selection figure] None本研究の目的は、ヒトにおけるコラーゲン合成に対するコルチコステロイド誘導効果について、トリヨードサイロ酢酸(TRIAC)とデヒドロエピアンドロステロン(DHEA)との組合せの効果を、TRIAC、DHEA又はプラシーボ単独との対比で調べることであった。年齢40～65歳の６人の健常男性ヒトボランティアが参加した。腹部皮膚の４つの領域を、ベタメタゾンバレレートクリームで３週間、前処置した。その後、同じ領域を、同じクリームビヒクル中の次の
