Procédés de modulation de l'expression et de l'agrégation de produit génétique à expansion CAG dans les cellules et procédés d'identification des agents utiles pour l'effectuer

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专利权人:

National Yang-Ming University

发明人:

申请号：

EP11167774.6

公开号：

EP2463372A1

申请日:

2011.05.26

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

This invention provides a method for modulating the expression of a first gene in a cell wherein the first gene is one containing more than 36 CAG trinucleotide repeats and encoding a protein that form polyglutamine-mediated protein aggregation. Suppression of the first gene is achieved by reducing the expression of SPT4 gene or SUPT4H gene. It can also be achieved by inhibiting the formation of a Spt4/Spt5 complex or a Supt4h/Supt5h complex. Also provided is a method for identifying an agent useful for modulating the expression and aggregation of CAG-expanded gene product, or treating a polyglutamine disease such as Huntington's disease.

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http://www.ckcest.cn/home/