This invention offers the interleukin - 11 (IL-11) analogs (mIL-11) and the living body polymer cup union which is formed with the living body compatibility polymer. It shows the tolerance where mIL-11 of this invention confronts Acid resolution and improves, in maturity rearrangement person IL-11 (rhIL-11) compares and it shows the stability which augments. Cup union of this invention designates a longer serum half-life as feature, when it compares with the non join mIL-11 which fits, does not show active loss substantially.< Choice figure >Drawing 8本発明は、インターロイキン-11(IL-11)類似体(mIL-11)及び生体適合性ポリマーで構成された生体ポリマー結合体を提供する。本発明のmIL-11は酸分解に対する向上した耐性を示し、成熟組換えヒトIL-11(rhIL-11)に比して増加した安定性を示す。本発明の結合体はより長い血清半減期を特徴とし、相応する非結合mIL-11と比較した場合、実質的に活性損失を示さない。【選択図】図8
