The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients for whom metformin therapy is inappropriate due to intolerability or contraindication against metformin.本發明係關於以下發現:某些DPP-4抑制劑特別適於治療及/或預防由於對二甲雙胍難耐受或禁忌而不適合二甲雙胍療法之患者的代謝疾病、特別是糖尿病。