Refers to a multi Molecule,Characterized in that it comprises: (1) a domain that includes a variable region of an Antibody with binding activity to glypican - 3 (2) a domain that includes a variable region of an Antibody binding activity of T cell receptor Complex and (3) a domain that includes a region On FC binding activity with reduced Towards a Fcgamma receptor.It also relates to a Nucleic Acid encoding a Molecule, a cell comprising Said Nucleic Acid, a Vector, a production method and a Pharmaceutical composition. The multi Molecule binds to the Antigen Bearing T cells close to expressing cells glypican - 3, being useful in the treatment of cancerSe refiere a una molecula multiespecifica, caracterizada porque comprende: (1) un dominio que comprende una region variable de un anticuerpo con actividad de union a glipicano-3 (2) un dominio que comprende una region variable de un anticuerpo con actividad de union al complejo receptor de celulas T y (3) un dominio que comprende una region Fc con actividad de union reducida hacia un receptor Fcgamma. Tambien se refiere a un acido nucleico que codifica dicha molecula, una celula que comprende dicho acido nucleico, un vector, un metodo de produccion y una composicion farmaceutica. Dicha molecula multiespecifica se unen al antigeno que llevan celulas T cercanas a las celulas que expresan glipicano-3, siendo utiles en el tratamiento del cancer
