CARLO FARINA;CARLA GHELARDINI;NEUROTUNE AG;PAOLA PETRILLO
发明人:
CARLO FARINA,CARLA GHELARDINI,PAOLA PETRILLO
申请号：
IL20149809
公开号：
IL201498A
申请日:
2009.10.13
申请国别(地区):
IL
年份:
2013
代理人:
摘要：
The use of dimiracetam in the treatment of chronic pain chronic pain induced by osteoarthritis, rheumatoid arthritis or autoimmune osteoarthrosis forms is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.
